ea0051oc1.1 | Oral Communications 1 | BSPED2017
Prasad Pallavi
, Mushtaq Talaq
11-beta-hydroxysteroid-dehydrogenase type 2 deficiency (11bHSD2) or syndrome of apparent mineralocorticoid excess is an autosomal recessive condition that characteristically presents with hypokalaemia and hypertension. In this condition, cortisol is not inactivated to cortisone and thus the excess cortisol cross reacts with the mineralocorticoid receptors in the kidney leading to hypertension, hypokalaemia and suppressed plasma renin activity (PRA) and aldosterone levels. The ...